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Creative organizing Is it just me?Or do you struggle with the concept of goodie bags for kid's parties, too?It seems a child doesn't go anywhere without ultimately coming home with something.As an organizer, i struggle with that.On the one hand, it is fun.On the other hand, i see it as contributing to a life long expectation that fun equals stuff or something sugary.Can't a party at school be enough fun without having to bring something home?Can't soccer be fun without the sugary drink and salty snack at the end? Health issues aside, the other thing that bothers me is that so much of the things in our treat bags don't get used.At least not by my kids.They just come into my home, clutter things up a bit and ultimately end up in the landfill.And i know i'm not alone in this.Having sorted through just a few toys in my days at my clients' homes as well. I guess it all sounds a little cynical.I know it does.And luckily the other side of me always chimes in and says"It's just for fun.Lighten up, aby! "And that side ultimately wins out. (My kids wouldn't have it any other way. ) So when party day rolls around, i'm always on the lookout for something inexpensive, usable and lasting.In other words, something that wont break the first time it's used.I also like one or two big items that wont get lost as soon as they're out of the bag, as opposed to a bunch of small stuff.For collin's birthday party, each child got this: I used oversized lunch bags and scrapbook supplies to make the tags.Each child got a curly straw(I haven't met a child yet that doesn't go nuts over curly straws.What's that all about, anyway? )And inside was a deck of jumbo playing cards, a small note book, a pen, and some tootsie rolls.So for a minimal investment, we gave the kids some items that can be used over again and aren't likely to break.In years past we've done little stuffed animals(When did target stop carrying those cute little stuffed animals i loved those for treat bags.Big yet inexpensive. )We've also given toy footballs(From the dollar store again, big, usable and not likely to break too quickly. ) How about you?How do you handle treat bags?Do you love them?Hate them?Wonder why on earth i'm suggesting you give them a second thought?And most of all.If you have any super great ideas for goodies.I'd love to hear it.In just four weeks, my daughter has her party!Thanks! I do enjoy putting together a"Creative"Goody bag.I seldom put candy in there except maybe a lollypop.I am not a huge fan of the allcandy and teeny tiny toy filled goodybags. For my son"Mystery"Party i put a mystery chapter book(From the book order at school), a gigantic magnifying glass, a notebook, a pencil and a lollypop. My son went to a party in january where they happened to ice skate but the"Goody bag"Was filled a packet of hot choco, some marshmellows, and a candy covered spoon.I loved that!It was used and"Done". Last year she had a tea party with her friends and each person got a bag with a cute tea cup that g chose from the thrift store, 2 packets of hot cocoa, a snack size baggie of minimarshmallows, a choc covered spoon that we made, and 2 mint hershey kisses to add to the cocoa.We also put in a spiral bound notebook(The small 3x5 with the spiral at the top)That we altered by covering with cardstock and put their name on with chipboard letters.It was one of my favorite gift bags. This year the place we having her party at does the gift bags as part of the party so i not involved with it at all.We are having a"Family"Party for her(Only 8 friends can come to the princess party place)So our extended family and faraway friends will come to the family party and i will do gift bags for them.She will probably want to keep the princess theme(Gotta love turning 6.So i not sure what i do for the gift bags.I was thinking of baking something yummy and decadent something"Fit for a princess! " I really do hate goodie bags for all the reasons you gave aby they just end up on the floor, junking up the house, making a mess, and driving me nuts and i don want to do that to another family. Goodie bags can be a challange.When my oldest turned 12 i bought the large hershey bars 1 for ea.Kid and made a band for ea.Bar in a fun print that said thanks for coming to my party.It was still candy but it was simple.Simple to make, carry and give out not to mention cheap. I always like the idea of the mini playdough cans w/an activity thing on the top.I think we get caught up in thinking it got to be a lot of goodies in one bag.I don think the kids really care.I never heard my kids say wow that was a lame goodie bag. My girls like to do crafts at their party.So usually the craft is the goodie to take home.We have made soap and the girls took them home in a cello bag and picked out their own cute ribbon to tie the bag.My 11 year old last year had 5 girls over and i had bought big canvases at walmart and put their names big in black in the middle.I had paint and brushes set up for them to decorate them.I had also pre drilled holes in each corner.The girls then picked out ribbon to put through the drilled holes and that was how they would hang them when they got home.It really is getting to be absurd.My dd just came home with a full size teddy bear this past saturday, plus a bag full of pinata candy and a glow in the dark necklace.To top that off the birthday child was"Registered"At target baby!We all gone quite mad, i do believe.I am having a party for my dd at the end of this month.Maybe i should put on the invitation: "Goodybagless party".Hahafor my son last birthday party, i had the kids complete a treasure hunt of sorts to get their goodie bag.His party was car, trucks and planesthemed so each child got a card with a little poem about some sort of vehicle.They really enjoyed"Earning"Them rather than just receiving them before they went home. I have long disliked bags just another thing to stress over.One year we had an zoo animal themed party so the only thing in the bag was peanuts.For my girls party last year, we made tiaras and jewelry with pipecleaners and pony beads and they took them home in a bag they decorated with sequins and feathers.This summer my son went to a friend party.This friend is an only child and his parents have tons o we, on the other hand, are a one income family with 7 children. (My kids get invited to parties all the time and it kills my budget. )So we just put some cash in a card and got him some candy and figured he could combine what we gave him with what he already had and get what he wanted.When i picked up my son, this friend mom told me to be sure to get the gift card out of the goodie bag.In the car i pulled it out and it was worth $25 at target.How many times does a kid go to a party and come home with a gift worth more than the one he took?I was a bit disturbed by it.I felt bad that we couldn afford to do more.I know that she wasn trying to make us feel bad, just being kind but it was a bit uncomfortable for me.What do you think of this? Let see.I did a pirate theme party for my son when he was six.It was so much fun to do something christian louboutin evenings a little out of the ordinary that wasn an"Outofthebox"Birthday party.I found a great book in the children section at the library on pirates(The name escapes me now).It was a fun humorous book that talked about the history of pirates as well as described what a pirate wears.It also had a chart for picking your own pirate name. My invitations included a condensed outline christian louboutin france of this and instructions on what to wear to the party(A striped shirt and shaggy old pants).It also asked the kids to come with their pirate name.Also in the invitation were homemade eyepatches. A goody bag was made from black cloth with a draw string.I painted a skull crossbones on each one.They included"Pieces of eight" (Chocolate gold coins), a note book with a pirate theme, a pirate pencil, and some tacky play jewelry for loot. For games the kids could win prizes from a costume shop like a sword, a hook hand, and a pirate hat. It was a blast.Best party ever. I with you on the goodie bags.I stopped doing them all together.They just seem wrong and as you say, a waste usually.My son is 12 and he has had sleep over parties the boys don seem to miss the bags at the end of those(Too tired? ! )I think the goodie bag thing has gotten way out of control, and each time i tell a mom i not doing it they rethink it.Some have also decided not to if you can influence the circle of friends it becomes more acceptable. Hey, how your running?Take care, lbtinpaserfemme vickie l. I posted earlier about the pirate theme party i did, but i just remembered a sleepover party i did for my daughter.I think she was about 11 or 12.Rather than goody bags i bought large tshirts for each of the girls.I created a design on the computer for her party, then we ironed the design on all the tshirts.The idea was to have them as a large pajama shirt for the girls.I also bought each of the girls a white pillow case that they each decorated with paint and markers.Both things were a nice reminder of the sleepover party. (She is 17 now, and still has both of them. )I suppose we could have expanded on the idea even more with some funky socks or fuzzy slippers.

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Management of ibd involves the use of 5asa and immunosuppressives such as corticosteroids and 6mercaptopurine as well as its precursor azathioprine.Novel agents such as monoclonal antibodies against tnf have been developed and demonstrate clinical efficacy.However, these agents are expensive and not without side effects.Consequently, there is a need for alternative agents that may be equally or more effective as well as being cheaper.Both curcumin and sulfasalazine target ikk molecules;The importance of inhibition of i?B kinase complex by curcumin has never been tested in ibd.Here researchers show that this compound has beneficial effects in a rat model of ibd, opening the door to possible future human studies. A new study http://www.teamskyuser.co.uk/ The new study now provides the first evaluation of curcumin and its effects on nf b in an experimental model of ibd.Salh, k.Assi, k.Parhar, d.Owen, and a.Gmezmuoz, at the jack bell research centre at the vancouver general hospital, and v.Templeman and k.Jacobson of the department of pediatric gastroenterology, children and women's hospital, all in vancouver, british columbia, canada.Their findings appear in the july 2003 edition of the american journal of physiologygastrointestinal and liver physiology.Sevenweekold c3h mice had inflammation induced with instillation of 100 l of dnb(60 mg/ml)In 50% ethanol with control animals receiving 100 l of 50% ethanol alone.After this, they were kept in position for 30 seconds before being returned to their cages.On day 5, postinduction was conducted for evaluation of the colitis.Test groups of five mice had curcumin added to their diet at a concentration of 0.25% beginning five days before the DNB instillation. Several parameters were determined in the inflamed mucosa.Animals were weighed daily after induction of colitis and the data shown are representative of all experiments.There was a clear reduction in the amount of weight loss in the animals pretreated with curcumin. Curcumin improves intestinal cell function in dnbinduced colitis.After treatment of animals, colons were harvested and histological evaluation was carried out after staining with hematoxylin and eosin.There was mucosal ulceration, thickening of the wall, and significant infiltration with inflammatory cells in the dnbtreated animals that is reduced in those animals pretreated with curcumin. When animals were pretreated with curcumin, there was a clear reduction in dna binding, thus verifying that curcumin does indeed inhibit nf b activation in the colon in vivo.These findings indicate for the first time that curcumin is able to impact on an important transcriptional mechanism in the gastrointestinal tract.In addition to the demonstration that it is able to diminish inflammatory activity in ibd, the canadian team demonstrated it can reduce nf b dna binding activity as well as inhibiting the activation of p38 mapk antibodies and that the antiinflammatory effects of curcumin involve a reduction in myeloperoxidase activity, a reduction in the number of infiltrating neutrophils, as well as a reduced expression of the message for il1. Precisely how curcumin achieves its effects is not clear.It has been shown to possess free radical scavenging(Antioxidant)Properties in addition to its known effects on the activation of nf b.Its in vivo effects may well rely on a complementation of these two and other activities. Although curcumin has been shown to be safe up to levels as high as 10 percent(100, 000 ppm), the researchers showed effectiveness at a concentration as low as 0.25 percent.This dose was well tolerated with no reduction in dietary intake.Further work will help to clarify the optimal dose for this and other models of ibd. This research proves that curcumin may prove to be a cheap, welltolerated, and effective therapy for inflammatory bowel disease.This food ingredient has for generations been regarded as a potent antiinflammatory within many eastern civilizations.It is equally intriguing that the same agent is a potent antineoplastic agent.It may hold promise for the treatment of ibd in humans. Source:July 2003 edition of the american journal of physiologygastrointestinal and liver physiology. The american physiological society(Aps)Was founded in 1887 to foster basic and applied science, much of it relating to human health.The bethesda, mdbased society has more than 10, 000 members and publishes 3, 800 articles in its 14 peerreviewed journals every year.

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Alpha induces tumor necrosis and tumor cheap beats by dre solo regression without systemic toxicity Tumortargeted gene delivery of tumor necrosis factor induces tumor necrosis and tumor regression without systemic toxicity Ralf kircheis1, elinborg ostermann1, markus f wolschek2, 3, cornelia lichtenberger3, christine maginlachmann1, lionel wightman1, malgorzata kursa1 and ernst wagner1received 14 may 2002. Top of pageabstractwe have recently developed surfaceshielded transferrin(Tf delivery systems that target reporter gene expression to distant tumors after systemic application.In the present study, we used surfaceshielded tf complexes for delivering the gene for a highly potent cytokine, tumor necrosis factor(Tnf tnf is known for its ability to induce hemorrhagic tumor necrosis and tumor regression.However, the therapeutic application of tnf is hampered by its high systemic toxicity dictating the need to target tnf activity to the tumor.Systemic application of surfaceshielded tf complexes with the tnf gene resulted in preferential expression of tnf in the tumor without detectable tnf serum levels, in contrast to the application of nontargeted complexes.Tumortargeted tnf gene delivery induced pronounced hemorrhagic tumor necrosis and inhibition of tumor growth in three murine tumor models of different tissue origins, neuro2a neuroblastoma, metha fibrosarcoma, and m3 melanoma, with complete tumor regressions observed in the metha model.No systemic tnfrelated toxicity was observed due to the localization of the tnf activity to the tumor.Targeted gene therapy may be an attractive strategy applicable to highly active, yet toxic, molecules such as tnf Keywords:Tumor necrosis factor;Tnf gene therapy;Tumor targeting;Polyethylenimine;Pei;Nonviral gene transfer;Transferrin The potential of gene therapy to target the expression of therapeutic genes to the desired target cells makes it particularly attractive for cancer treatment.However, although there are vectors available with high transfection efficacy in cell culture, 1, 2, 3, 4 efficient and targetspecific gene delivery in vivo is still the major challenge in gene therapy.In vivo gene delivery has to overcome additional obstacles such as anatomical size constraints and nonspecific interactions with biological fluids and nontarget cells.Recently, we have developed surfaceshielded transferrin(Tf gene delivery systems that are able to target reporter gene expression to distant tumors after systemic application in murine models.5, 6, 7 In the present study, we have employed these gene delivery systems to target gene expression of a highly potent, yet highly toxic, molecule tumor necrosis factor(Tnf to distant tumors with the aim to separate the antitumor activity of tnf from its systemic toxicity. In the present study, surfaceshielded tf gene delivery systems were used for the first time to target gene expression of a highly potent effector molecule to distant tumors following systemic application.Tnf expression localized to the tumor resulted in hemorrhagic tumor necrosis and inhibition of tumor growth without systemic tnfrelated toxicity. Top of pagematerials and methodschemicals and expression vectorspei, branched, 25 kda, and linear pei, 22 kda, were obtained from aldrich(Milwaukee, wi)And mbi fermentas(St.Leonrot, germany), respectively.Tf(25kDa)Synthesis has been described previously.7 The plasmids pcmvl, pcmv and pgsmutnf coding for luciferase,(And murine tnf respectively, and the nonexpressing plasmid psp65 were purified by elim biopharmaceuticals(San francisco, ca).Endotoxin levels were u/50 dna as determined by limulus amebocyte lysate assay(Biowhittaker, walkersville, md). Cells and animalsmurine neuro2a neuroblastoma cells were cultured in rpmi 1640 medium/10% fcs.Murine m3 melanoma cells were cultured in ham's f10 chpdrdrebts medium/15% horse serum/5% fcs.Murine metha fibrosarcoma cells(Kindly provided by dr fichtner, maxdelbr center, berlinbuch, germany)Were passaged in vivo as intraperitoneal ascites in syngeneic balb/c mice.A/j, dba/2, and balb/c mice(7 weeks, female)Were purchased from harlan(Bicester, uk). Preparation of transfection complexespei/dna complexes were prepared as described.7 Plasmid DNA(200 was flashmixed with PEI(22 kDa)Atn/p(N/p ratio of pei nitrogen to dna phosphate)In 20 mm hepes(Ph for isoosmolarity, glucose was added to a final concentration of 5%(Wt/vol).The potential of transfection complexes was measured using a malvern zetasizer 3000 as described previously.6 Tf complexes were prepared as described previously7 by flash mixing of dna(200 withthe polycation solution(Containing three parts pei and one part tf at n/p complexes were prepared in 20 mm hepes(Ph glucose or 0.5 HBS(75 mM NaCl, 20 mM HEPES, pH glucose. Determination of luciferase reporter gene expression after systemic applicationa/j mice were injected subcutaneously with 1 neuro2a cells.After 2 weeks, tumors had reached 10 in size;Transfection complexes(250 with the pCMVL plasmid were injected into the tail vein.Animals were sacrificed by cervical dislocation at indicated time points.Organs were resected, homogenized in250 mm tris buffer, ph 7.5, using an IKA Homogenizer, frozen in liquid nitrogen, and stored at Luciferase activity in the tissue lysate was measured using a Lumat LB9507 instrument(Berthold, bad wildbad, germany)As described previously.5 Luciferase background(100 RLU)Was substracted from each value and transfection efficacy is expressed as rlu(Relative light units)Per organ.One million rlu correspond to 2 ng of luciferase. Therapeutic modelsa/j mice were injected subcutaneously with 1 syngeneic neuro2a tumor cells, dba/2 mice were injected with 1 m3 cells, and balb/c mice were injected with 2 metha cells.Starting at indicated time points after tumor setting(Tumor diameter, 5 mm), transfection complexes containing the plasmid for murine TNF for a control plasmid for or the nonexpressing pSP65 plasmid were injected into the tail vein.Tumor size and body weight of the animals were monitored.Differences in Tumor growth were statistically analyzed using oneway anova(Tumor growth)And contingency tables(Tumor necrosis, complete tumor regression)Analyzed by chisquare test and fisher's exact test, using graphpad prism software. Histologyfor immunohistologicAl stAining,Cryosections(7 on microslides were fixed inCold Acetone.Endogenous peroxidAse wAs quenched By incuBAting the slides in hydrogen peroxide(SigmA, st.Louis, mo;0.03% in PBS), slides were Blocked with 1% BSA for 15 minutes, with 10% goAt serum for 15 minutes, And suBsequently with DAKO Biotin Blocking System(DAko,CArpinterA,CA).Following incuBAtion with either rAt Anti mAcrophAge f4/80 mAB(CloneCl:A31, 10 serotec, oxford, uk)Or rAt AntiCd11B mAB(Clone m1/70, 6.25 PhArmingen, SAn Diego,CA), detection wAs performed with diAminoBenzidine(DAB)Using A Anti igg hrp detection kit(PhArmingen)According to the mAnufActurer's instructions.HemAtoxylin(Merck, ViennA, AustriA)StAining wAs done using A stAndArd procedure.Slides were mounted with entellAn new medium(Merck)And evAluAted under An olympus(ViennA, AustriA)Bh2 microscope equipped with An olympus dp12CAmerA.An unspecific expression profile with high luciferAse expression in the lungs And other mAjor orgAns wAs oBserved with pei22/dnAComplexes(Fig 1A).InContrAst, surfAceshielded tfComplexes resulted in specific expression in the tumor, whereAs expression in the lungs And other orgAns wAs drAmAticAlly reduced(Fig 1B).The kinetics of luciferAse reporter gene expression wAs meAsured following single orRepeAted ApplicAtionof surfAceshielded tfComplexes in the tAil vein of tumorBeAring mice.Gene expression wAs trAnsient, with the single ApplicAtion showing A peAk At 48 hours, thereAfter decreAsing to very low expression levels At dAy 4, And noLuciferase activitywAs detectABle At dAy 7.RepeAted ApplicAtion(dAys0 And 1)Resulted in higher expression levels At All time points, And significAntLuciferase activitywAs still detectABle in the tumor 1 week After ApplicAtion(Fig 1c).NontArgeted pei22/dnA(A)Or targeted tfComplexes(B)Containing the pcmvl plasmid were injected into the tail vein of neuro2a tumorbearing mice.Luciferase activity(Rlu/organ;Mean was measured 24 hours after injection.C: Kinetics of gene expression After systemic ApplicAtion of tArgeted TfComplexes. TrAnsfectionComplexesContAining 50 of DNA were injected once (dAy0)Or twice(dAys0 And 1).Luciferase reporter gene expression was measured at indicated time points.Animal number was n per time point. Full figure and legend(328K) Localization of tnf beats by dre sale online activity to the tumorthe aim of this study was to target gene expression of the highly potent cytokine tnf to the tumor in order to reduce the systemic toxicity observed with systemic application of tnf using nontargeted pei22/dna[tnf complexes resulted in an unspecific gene expression pattern with highest tnf expression detected in the lungs, followed by the liver, heart, and tumor.Moreover, application of pei22/dna[tnf complexes was associated with significant tnf serum levels(Fig 2a).In control animals receiving similar pei22/dna complexes with the reporter gene instead of the tnf gene, no significant tnf levels were found(Data not shown).Lower tnf levels were found in liver and spleen.Importantly, no significant tnf levels were observed in the serum(Fig 2b).In comparison, tnf expression after application of nonshielded pei22/dna[tnf complexes was even shorter with peak levels in the lungs and serum 24hours after application, followed by a rapid decrease(Fig 2a, insert).A/j mice bearing a subcutaneously growing neuro2a tumor were injected with nontargeted(A, c, e)Or targeted(B, d, f)Transfection complexes containing a plasmid for mutnf or the nonexpressing plasmid psp65(C expression of murine tnf(Pg/organ)In the major organs and tumor, and tnf serum levels(Pg/ml)24 hours after single application were measured by ELISA(A, b, inserts:48 hours after single application).Body weight(C, d)And tumor size(E, f)Of animals(Eight per group)Treated with repeated application(Arrow heads)Of transfection complexes were monitored.Untreated animals are shown for control.Complexes were applied repeatedly at indicated time points into the tail vein.Control animals were left untreated or injected with complexes having the empty plasmid vector psp65.Body weightof the animals, as an indicator of TNF toxicity, was monitored during treatment (Fig 2, c and d). A significant drop inBody weightof 10% was found with nonshielded PEI/DNA[TNF complexes after the first two applications (P tnf versus control) (Fig 2c).There was no further weight loss after the following applications;However, in one out of two experiments, nonshielded pei/dna [tnf complexes resulted in the death of 2/8 animals.Nontargeted pei/dna[tnf complexes also inhibited tumor growth(P tnf versus untreated control) (Fig 2e), however, to a lesser extent compared to the targeted complexes(P targeted tnf versus nontargeted tnf complexes with the psp65 control plasmid did not significantly inhibit tumor growth;Similar results were observed with additional control complexes with the reporter gene(Data not shown). The most striking effect of the tnf gene therApy wAs theInduction of hemorrhagic tumor necrosis(Fig 3, A And B).More thAn 80% of the tnf AnimAlsDeveloped hemorrhAgic tumor necroses, whereAs hemorrhAgic tumor necrosis wAs virtuAlly not found inControl AnimAls(P tnf versusControl)And only rArely found in psp65 or AnimAls(P tnf versus or psp65) (Fig 3c).Necrosis wAs most pronounced in theCenter of the tumor.However, there wAs only in very fewCAses AComplete erAdicAtion of the tumor in this model.AfterCessAtion of treAtment, tumorCells locAted outside of the necrotic AreAs stArted to regrow.The therApeutic efficAcy of tArgeted tnf geneDeliveryCorrelAted with the numBer of ApplicAtions.Preexperiments on A smAll numBer of AnimAls with single ApplicAtion showed only moderAte therApeutic effect And high vAriABility Among the AnimAls not Allowing significAntConclusions(DAtA not shown).ToCompAre the therApeutic efficAcy ofDifferent treAtment regimes, the t/c rAtio(Tumor growth in treAted groupCompAred toControl group)WAs meAsured AfterDifferent numBers of ApplicAtions.A rAtio of t/c is generAllyConsidered indicAtive for A significAnt therApeutic effect.Four ApplicAtions of tnf gene therApy showed A significAnt therApeutic effect with A rAtio of t/c however, there wAs A vAriABility in the treAtment group.Six or eight ApplicAtions of tArgeted tnf gene trAnsferComplexes resulted in A t/c rAtio of 25% or 13%, respectively, indicAting higher efficAcy with higher numBer of ApplicAtions.Furthermore, increAsing the numBer of ApplicAtion Also minimized the vAriABility Among the AnimAls in the treAtment groups(Fig 3d).Further experimentsDemonstrAted thAt hemorrhAgic tumor necrosis And inhiBition of tumor growth were induced only By trAnsfectionComplexesCoding for tnf whereAsCytokines with A more indirect immunemediAted mechAnism of Action, such As interleukin2 or interferonDid not show significAnt efficAcy in this Aggressive tumor model(DAtA not shown).Neuro2A tumorBeAring A/j mice were injected with tArgeted trAnsfectionComplexesContAining expression plAsmids for(A)Mutnf or(B)C:Summary table.Induction of hemorrhagic tumor necrosis.Results of three independent experiments are shown. TNF versus pSP65, AndControl.D: TherApeutic efficAcy of TNF gene therApy AfterDifferent treAtment regimes (Four, six, or eight applications)Was estimated by the t/c ratio(tumor growth group versusControl group) AtDAy 21.

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Colorado pot accidents spur call for childproof packaging Robin hackett, owner of botana care in northglenn, colo., putting medical marijuana suckers into a sample zipperlock baggie. (Joe amon/the denver post) From early 2005 to late 2009, children's hospital colorado had exactly zero emergencyroom visits by kids who had ingested marijuana.In the following two years, when medical marijuana became legal in colorado and federal officials backed off prosecution, it had 14. Pioneering studies of emergency room charts by colorado doctors show looser pot laws leading to childhood poisonings, often ristianlbtinaussuressoldes from mistakenly eating tantalizing"Edibles' like gummy worms or brownies. Those doctors are now helping lead the charge for mandatory safety packaging as colorado gears up for even broader legal sales of pot with recreationalmarijuana stores. "We've seen a dramatic increase in pediatric exposure, ' said dr.George wang, a children's er doctor who also works with denver health's rocky mountain poison and drug center. Calls about potential marijuana exposure at all ages have doubled since 2009 at the poison center. Safety packaging, as in other medicines,"Is a supplement to careful parenting that has been shown to work,' said wang's colleague, dr.Michael kosnett. "There are solutions available right now.' And the marijuana christian louboutin platforms sale industry agrees, up to a point. Many industry members favor sending goods out the store door under tamperproof seal.But they would rather not break each individual joint or candy into a hightech, lockable bag whose cost up to $7, even in bulk might approach the price of the brownie inside. Have to buy so much tamperproof packaging that people will just make it themselves at home,' said robin hackett, coowner of botana care, a medicalmarijuana store in northglenn. "The challenge is with a pound of butter and some cannabis, anybody can make edibles.' Hackett and other members of the medical marijuana industry group say lockboxes and larger locking bags that buyers can use to transport larger purchases home should solve most of the safety problems. Breaking everything down into smaller tamperproof bags is a landfill problem and unnecessary expense, hackett said.Botana care counsels patients with children about safety, and keeps track of who has kids as a reminder. "Unfortunately, we can't christian louboutin homme write laws around dumb, ''"She said. None of the accidentally poisoned children has died, wang and kosnett said. There are serious medical consequences for small children, though, even while marijuana advocates say an adult"Overdose' of pot is nearly impossible. Prescribed dosages of thc, the active ingredient in marijuana products used to control nausea from chemotherapy, is between 4 and 12 milligrams for children ages 2 to 4, based on body surface area.Some"Edibles' have 300 milligrams of thc, kosnett said. The researchers say individual safety packs would be best, but the current recommendation of all items leaving the store in one secure package is"Better than nothing. " Because there is no clear reporting category for marijuana poisonings, doctors have to cull through files to count cases.Presbyterian/st.Luke's, which operates rocky mountain hospital for children, said it does not track similar cases. The cases studied at children's included decreased levels of consciousness and breathing trouble.Children can also vomit from ingesting too much of a strong substance and aspirate the vomit. The median age in the 14 patients was 3 years, and the range was 8 months to 12 years, according to an abstract of the research published in the journal clinical toxicology. Childingested pot is also dangerous because er doctors aren't looking for it as a cause of any symptoms they see, wang said.That can lead to invasive and expensive diagnostic efforts, such as a spinal tap or ct scan, if parents are embarrassed or scared to mention the true cause. "When children get admitted to the icu, that's serious, ' kosnett said.Symptoms may appear similar to meningitis, for example. Safety packaging and parental prevention should be noncontroversial, said dr.Robert brockmann, president of the colorado academy of family physicians, especially as newly legal recreational use will greatly expand the supply. "None of that information is being disseminated when it's dispensed,' brockmann said. "It's like liquor or prescription medications, or anything else you don't want your kids to get into.' Such measures have cut pediatric poisonings in various categories by 40 to 90 percent over the decades, he said.

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Clorox reports solid sales and margin growth in first quarter Net cash provided by operations increased to $208 million from $131 million in the yearago quarter.The yearoveryear increase was due primarily to favorable changes in working capital.For the full fiscal year, clorox anticipates free cash flow of about 9 percent to 10 percent of sales.The company defines free cash flow as cash provided by operations less capital expenditures.In september, the company issued $600 million of 10year senior notes, temporarily increasing its cash balance prior to the midoctober repayment of other maturing longterm debt of $350 million.The company's cash balance is expected to return to a more normalized level by dec.31. 11% pretax earnings increase Volume growth in the segment was driven primarily by high doubledigit growth in the professional products business, due to the benefit of acquisitions made in fiscal 2012 and a doubledigit increase in the base business.Shipments in the home care business were about equal to the year ago quarter, with alltime record shipments of clorox disinfecting wipes, offset by declines on pinesol products due to a price increase in the fourth quarter of fiscal 2012.Home care sales increased due to the benefit of beats by dre uk price increases.Laundry volume decreased due to lower shipments of clorox 2 stain fighter and color booster, partially offset by the highest volume growth of bleach in more than two years.Segment sales outpaced volume largely due to the benefit of price increases.Pretax earnings growth was driven primarily by higher sales and the benefit of strong cost savings, partially offset by unfavorable product mix. 19% beats by dre sale online pretax earnings increase The segment's volume and sales decreases were driven primarily by declines in the charcoal business, reflecting the impact of price increases earlier in the calendar year and the comparison to very strong merchandising and volume growth in the yearago quarter.Cat litter volume declined due to price increases implemented in the fourth quarter of fiscal 2012 and increased competitive activity.Glad volume was up, with continued strong gains in premium trash bag products such as glad odorshield trash bags with febreze.The variance between the changes in segment volume and sales was primarily due to the benefit of price increases.Pretax earnings growth was driven largely by strong cost savings, partially offset by lower sales. 2% pretax earnings increase drdrebtshdphones Volume was up in the food business driven primarily by higher shipments of hidden valley products, offset by lower shipments of kc masterpiece products due to strong competitive activity.Volume declined in the water filtration business due to lower shipments of faucet mount products, as well as lower brita bottle shipments, compared to strong volume behind the new product launch in the prioryear quarter.Burt's bees shipments declined slightly, following strong growth in the yearago period, behind a robust pipeline of new products.Burt's bees delivered doubledigit retail sales growth.Segment sales grew primarily due to the benefit of price increases.Pretax earnings growth reflected the benefit of cost savings. 30% pretax earnings decrease Volume declined in the segment largely due to the exit of nonstrategic export businesses.Base business in latin america grew both volume and sales, while canada volume and sales declined slightly.Segment sales increased primarily due to price increases, partially offset by unfavorable foreign exchange.The pretax earnings decline of $12 million was due to the inflationary impact on manufacturing and logistics costs, unfavorable foreign exchange and expenses associated with it systems implementation in latin america.Clorox markets some of the most trusted and recognized brand names, including its namesake bleach and cleaning products, clorox healthcare", HealthLink, Aplicare and Dispatch products, Green Works naturally derived home care products, PineSol cleaners, Poett home care products, Fresh Step cat litter, Glad bags, wraps and containers, Kingsford charcoal, Hidden Valley and KC Masterpiece dressings and sauces, Brita waterfiltration products, and Burt's Bees and gud natural personal care products.Nearly 90 percent of the company's brands hold the no.1 or No.2 market share positions in their categories.The company's products are manufactured in more than two dozen countries and marketed in more than 100 countries.Clorox is committed to making a positive difference in the communities where its employees work and live.Founded in 1980, the clorox company foundation has awarded cash grants totaling more than $87 million to nonprofit organizations, schools and colleges.In fiscal year 2012 alone, the foundation awarded $3.5 million in cash grants, and Clorox made product donations valued at $15 million. Forwardlooking statementsthis press release contains"Forwardlooking statements"Within the meaning of section 27a of The securities act of 1933, as amended(The securities act),AndSection 21E of the Securities Exchange Act of 1934, as amended(The exchange act),Andsuch forwardlooking statements involve risksAnduncertainties.Except for historical information, matters discussed above, including statements about future volume, sales, costs, cost savings, earnings, cash flows, Plans,objectives, expectations, growth, or profitability, are forwardlooking statements based on management's Estimates,assumptionsAndprojections.Words such as"Will," "Could," "May," "Expects," "Anticipates," "Targets," "Goals," "Projects," "Intends," "Plans," "Believes," "Seeks," "Estimates,"And variations on such words,Andsimilar expressions, are intended to identify such forwardlooking statements.These forwardlooking statements are only predictions, subject to risksAnduncertainties,Andactual results could differ materially from those discussed above.Important factors that could affect performanceAndcause results to differ materially from management's expectations are described in the sections entitled"Risk factors"And"Management's DiscussionAndAnalysis of Financial ConditionAndResults of Operations"In the annual report on form 10k for the fiscal year ended june 30, 2012, as updated from time to time in the company's sec filings.These factors include, but are not limited to: the company's costs, including volatilityAndincreases in commodity costs such as resin, diesel, chloralkali, sodium hypochlorite, highstrength bleach, agricultural commoditiesAndother raw materials;Increases in energy costs; the ability of the company to implementAndgenerate expected savings from its programs to reduce costs, including its supply chain restructuringAndother restructuring plans;Supply disruptions or any future supply constraints that may affect key commodities or product inputs;Risks inherent in relationships with suppliers, including solesource or singlesource suppliers;Risks related to the handling and/or transportation of hazardous substances, including, but not limited to, chlorine;The success of the company's strategies; the ability to manageAndrealize the benefits of joint venturesAndother cooperative relationships, including the company's joint venture regarding the company's Glad plastic bags, wrapsAndcontainers business,Andthe agreements relating to the provision of information technology, procure to payAndother key services by third parties; risks relating to acquisitions, mergersAnddivestitures,Andthe costs associated therewith; risks inherent in maintaining an effective system of internal controls, including the potential impact of acquisitions or the use of thirdparty service providers,Andthe need to refine controls to adjust for accounting, financial reportingAndother organizational changes or business conditions; the ability of the company to successfully manage tax, regulatory, product liability, intellectual property, environmentalAndother legal matters, including the risk resulting from jointAndseveral liability for environmental contingenciesAndrisks inherent in litigation, including class action litigationAndInternational litigation; risks related to maintainingAndupdating the company's information systems, including potential disruptions, costsAndthe ability of the company to implement adequate information systems in order to support the current businessAndto support the company's potential growth;The ability of the company to develop commercially successful products that delight the consumer; consumerAndcustomer reaction to price changes;Actions by competitors;Risks related to customer concentration; customerspecific ordering patternsAndtrends;Risks arising out of natural disasters;The impact of disease outbreaks, epidemics or pandemics on the company's, suppliers' or customers' operations;Changes in the company's tax rate; unfavorable worldwide, regional or local general economicAndmarketplace conditionsAndevents, including consumer confidenceAndconsumer spending levels, the rate of economic growth, the rate of inflation or deflation,Andthe financial condition of the company's customers, suppliersAndservice providers; foreign currency exchange rate fluctuationsAndother risks of international operations, including governmentimposed price controls; unfavorable political conditions in the countries where the company does businessAndother operational risks in such countries; the impact of the volatility of the debtAndequity markets on the company's cost of borrowing, cost of capitalAndaccess to funds, including commercial paperAndits credit facility; risks relating to changes in the company's capital structure, including risks related to the company's ability to implement share repurchase plansAndthe impact thereof on the company's capital structureAndearnings per share; the impact of any unanticipated restructuring or assetimpairment chargesAndthe ability of the company to successfully implement restructuring plans;Risks arising from declines in cash flow, whether resulting from declining sales, higher cost levels, tax payments, debt payments, share repurchases, higher capital spending, interest cost increases greater than management's expectations, interest rate fluctuations, increases in debt or changes in credit ratings, or otherwise; the costsAndavailability of shippingAndtransport services;Potential costs in the event of stockholder activism;Andthe company's ability to maintain its business reputationAndthe reputation of its brands. The company has disclosed information related to sales growth, gross margin and diluted eps on a nongaap basis to supplement its condensed consolidated statements of earnings presented in accordance with gaap.These nongaap financial measures exclude certain items that are included in the company's results reported in accordance with gaap, including charges associated with simplification of the company's supply chain and other restructuringrelated charges and the impact of foreign exchange and foreign currency exchange transactions and acquisitions. Management believes that these nongaap financial measures provide useful additional information to investors about current trends in the company's operations and are useful for periodoverperiod comparisons.These nongaap financial measures should not be considered in isolation or as a substitute for the comparable gaap measures.In addition, these nongaap measures may not be the same as similar measures provided by other companies due to potential differences in methods of calculation and items being excluded.They should only be read in connection with the company's condensed consolidated statements of earnings presented in accordance with gaap.

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